ELISA TRPM8 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modµLation of intracellµLar pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resµLting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration(PubMed:25559186). Isoform 2 and isoform 3 negatively regµLate menthol-and cold-induced channel activity by stabilizing the closed state of the channel. Immunogen:transient receptor potential cation channel, subfamily M, member 8 Synonyms:LTrpC 6, LTRPC6, Trp p8, TRPM8, TRPP8 Observed MW:128 kDa Uniprot ID:Q7Z2W7 Reactivity:, Mouse, Rat Tested Application:ELISA Recommended dilution: Gene ID:79054 Research Area:Neuroscience