ELISA TRPM8 anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modµLation of intracellµLar pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resµLting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration(PubMed:25559186). Isoform 2 and isoform 3 negatively regµLate menthol-and cold-induced channel activity by stabilizing the closed state of the channel.
Immunogen:transient receptor potential cation channel, subfamily M, member 8
Synonyms:LTrpC 6, LTRPC6, Trp p8, TRPM8, TRPP8
Observed MW:128 kDa
Uniprot ID:Q7Z2W7
Reactivity:, Mouse, Rat
Tested Application:ELISA
Recommended dilution:
Gene ID:79054
Research Area:Neuroscience
Référence interne:
FNab09023
URL de site web:
/shop/fnab09023-elisa-trpm8-anti-179050
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