Human Retinol-binding protein 4 Mab

Mouse anti- Human Retinol-binding protein 4 monoclonal antibody Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.For more information about different types of antibodies and their properties, please visitWikipedia Antibody. For information on functions, splicing variants and sequences of the target protein, please visitUniProt.org. For expression levels and tissue distribution of the target protein please visitbioGPS.org.Download the user's guide with the link at bottom of page. - 100 ug