pMEVHA-JNKK1-K131M

Human JNKK1 (MAP2K4) Xpress Clones Mitogen-activated protein kinases (MAPKs) cascade relays extracellular signals from cell membrane to the nucleus to induce intracellular responses and to regulate many aspects of cell physiology. These cascades, including JNK, ERK and p38 pathways, consist of distinct members of regulatory enzymes that serially activate one another in response to growth factors, cytokines and other mitogenic stimuli, leading to (in)activation of transcription factors. Like ERK1/2 and p38, the JNK activation requires dual phosphorylation on tyrosine and threonine residues within a conserved TPY motif. Activated JNKK1/2 can preferably phosphorylate and activate JNKs, with JNKK2 more specific to JNK. - 20 ug