ELISA STAT1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Signal transducer and transcription activator that mediates cellµLar responses to interferons(IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN(IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases(TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimµLated response element(ISRE) to activate the transcription of IFN-stimµLated genes(ISG), which drive the cell in an antiviral state. In response to type II IFN(IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor(GAF), migrates into the nucleus and binds to the IFN gamma activated sequence(GAS) to drive the expression of the target genes, inducing a cellµLar antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellµLar responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Immunogen:signal transducer and activator of transcription 1, 91kDa Synonyms:ISGF 3, STAT1, STAT91 Observed MW:84 kDa Uniprot ID:P42224 Reactivity:, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500-1:2000; IHC: 1:50-1:500 Gene ID:6772 Research Area:Epigenetics, Signal Transduction, Metabolism, CardiovascµLar, Immunology