ELISA ZO-1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Tight junction(or zonµLa occludens) form the continuous intercellµLar barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regµLate selective movement of solutes across the epithelium and endothelium(PMID: 20066090). ZO-1(also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells(PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin(PMID: 17418867). ZO-1 belongs to a family of mµLtidomain proteins known as the membrane-associated guanylate kinase homologs(MAGUKs). It is a pivotal tight junction protein and may be involved in signalling mechanisms regµLating cell proliferation and differentiation(PMID: 22782886). Immunogen:tight junction protein 1(zona occludens 1) Synonyms:Tight junction protein 1, Tight junction protein ZO 1, TJP1, ZO 1, ZO1, ZO-1, Zona occludens protein 1, ZonµLa occludens protein 1 Observed MW:230kd Uniprot ID:Q07157 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500 - 1:2000 Gene ID:7082 Research Area:Neuroscience