ELISA VPS4A anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Involved in late steps of the endosomal mµLtivesicµLar bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimµLated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission(PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413). Immunogen:vacuolar protein sorting 4 homolog A(S. cerevisiae) Synonyms:FLJ22197, hVPS4, Protein SKD2, SKD1, SKD2, VPS4, VPS4 1, VPS4A Observed MW:49 kDa Uniprot ID:Q9UN37 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:200-1:1000 Gene ID:27183 Research Area:Metabolism