ELISA USP33 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellµLar migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regµLation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellµLar domain of ROBO1, leading to regµLate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regµLator of G-protein coupled receptor(GPCR) signaling by mediating the deubiquitination of beta-arrestins(ARRB1 and ARRB2) and beta-2 adrenergic receptor(ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimµLation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This sµggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regµLating thyroid hormone regµLation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains. Immunogen:ubiquitin specific peptidase 33 Synonyms:Deubiquitinating enzyme 33, hVDU1, KIAA1097, Ubiquitin thiolesterase 33, USP33, VDU1 Observed MW:107 kDa Uniprot ID:Q8TEY7 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:200-1:2000; IHC: 1?20-1?200 Gene ID:23032 Research Area:Epigenetics, Metabolism