ELISA ULBP1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Ligand for the KLRK1/NKG2D receptor, together with at least µLBP2 and µLBP3. µLBPs activate mµLtiple signaling pathways in primary NK cells, resµLting in the production of cytokines and chemokines. Binding of µLBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein µL16. The interaction with µL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. µL16 also causes µLBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Immunogen:µL16 binding protein 1 Synonyms:ALCAN beta, N2DL 1, N2DL1, NKG2D ligand 1, NKG2DL1, RAET1I, µL16 binding protein 1, µLBP1 Observed MW:30 kDa, 37 kDa Uniprot ID:Q9BZM6 Reactivity:, Mouse Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:200-1:2000; IHC: 1?20-1?200 Gene ID:80329 Research Area:Cancer