ELISA UBA52 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Ubiquitin: Exists either covalently attached to another protein, or free(unanchored). When covalently bound, it is conjµgated to target proteins via an isopeptide bond either as a monomer(monoubiquitin), a polymer linked via different Lys residues of the ubiquitin(polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin(linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD(endoplasmic reticµLum-associated degradation) and in cell-cycle regµLation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjµgated to Lys residues of target proteins, however, in rare cases, conjµgation to Cys or Ser residues has been observed. When polyubiquitin is free(unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. 60S ribosomal protein L40: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellµLar transcripts, and especially for cap-dependent translation of vesicµLar stomatitis virus mRNAs. Immunogen:ubiquitin A-52 residue ribosomal protein fusion product 1 Synonyms:UBA52, UBCEP2, HUBCEP52, CEP52, RPL40 Observed MW:118 kDa Uniprot ID:P62987 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC Recommended dilution:IHC: 1:20-1:200 Gene ID:7311 Research Area:Immunology, Metabolism