ELISA Tuberin-Specific anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein(GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimµLated phosphorylation of S6K1 and EIF4EBP1 by negatively regµLating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubµLe-mediated protein transport, but this seems to be due to unregµLated mTOR signaling. TSC2 stimµLates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1(hamartin) gene cause tuberous sclerosis complex(TSC), an autosomal dominant disorder characterized by development of mµLtiple, widespread non-malignant tumors. The antibody is specific to TSC2. Immunogen:tuberous sclerosis 2 Synonyms:FLJ43106, LAM, TSC2, TSC4, Tuberin, tuberous sclerosis 2, Tuberous sclerosis 2 protein Observed MW:200 kDa Uniprot ID:P49815 Reactivity:, Mouse Tested Application:ELISA, WB, IF, IHC Recommended dilution:WB: 1:200-1:2000; IHC: 1:20-1:200?IF: 1:10-1:100 Gene ID:7249 Research Area:Cell Division and Proliferation