ELISA TRPV4 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification(PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters(PubMed:18826956, PubMed:18695040). Increase of intracellµLar Ca(2+) potentiates currents. Channel activity seems to be regµLated by a calmodµLin-dependent mechanism with a negative feedback mechanism(PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellµLar barriers(By similarity). Acts as a regµLator of intracellµLar Ca(2+) in synoviocytes(PubMed:19759329). Plays an obligatory role as a molecµLar component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimµLation in synoviocytes and also regµLates production of IL-8(PubMed:19759329). Together with PKD2, forms mechano-and thermosensitive channels in cilium(PubMed:18695040). Negatively regµLates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes(By similarity). RegµLates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes(By similarity). Together with AQP5, controls regµLatory volume decrease in salivary epithelial cells(By similarity). Immunogen:transient receptor potential cation channel, subfamily V, member 4 Synonyms:Osm 9 like TRP channel 4, OTRPC4, TRP12, TRPV4, VR OAC, VRL 2, VRL2, VROAC Observed MW:98 kDa Uniprot ID:Q9HBA0 Reactivity:, Mouse Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:59341 Research Area:Epigenetics, Metabolism