ELISA TRIM24 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modµLates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4'(H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regµLation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regµLates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor(TR) and ESR1. ModµLates transcription activation by retinoic acid(RA) receptors, including RARA. Plays a role in regµLating retinoic acid-dependent proliferation of hepatocytes(By similarity). Immunogen:tripartite motif-containing 24 Synonyms:HTIF1, PTC6, RING finger protein 82, RNF82, TF1A, TIF1, TIF1 alpha, TIF1A, TIF1ALPHA, TRIM24, tripartite motif containing 24 Observed MW:117 kDa Uniprot ID:O15164 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IP Recommended dilution:WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:50-1:500 Gene ID:8805 Research Area:Metabolism