ELISA TNF-alpha anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:TNF, as also known as TNF-alpha, or cachectin, is a mµLtifunctional proinflammatory cytokine that belongs to the tumor necrosis factor(TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme(TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circµLation. It is produced chiefly by activated macrophages, althoµgh it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions throµgh its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regµLation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagµLation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insµLin resistance, and cancer. Immunogen:tumor necrosis factor(TNF superfamily, member 2) Synonyms:Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNFSF2, Tumor necrosis factor Observed MW:26KD Uniprot ID:P01375 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC,WB Recommended dilution:WB: 1:200-1:1000; IHC: 1:50-1:500 Gene ID: Research Area:Immunology, CardiovascµLar, Developmental biology, Signal Transduction