ELISA TEAD4 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ Quantity control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regµLatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regµLatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regµLating cell proliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons'(5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. Immunogen:TEA domain family member 4 Synonyms:RTEF1, TCF13L1, TEF3 Observed MW:65 kDa Uniprot ID:Q15561 Reactivity:, Mouse, Rat Tested Application:ELISA, IP, WB Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000 Gene ID:7004 Research Area:CardiovascµLar, Metabolism