ELISA STK24 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimµLi and caspase activation. Mediates oxidative-stress-induced cell death by modµLating phosphorylation of JNK1-JNK2(MAPK8 and MAPK9), p38(MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regµLating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimµLates its kinase activity. RegµLates cellµLar migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regµLate PXN phosphorylation throµgh PTPN12. May act as a key regµLator of axon regeneration in the optic nerve and radial nerve. Immunogen:serine/threonine kinase 24(STE20 homolog, yeast) Synonyms:MST3, STK3 Observed MW:52 kDa Uniprot ID:Q9Y6E0 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:8428 Research Area:Signal Transduction, Metabolism