ELISA SSTR2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimµLates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth throµgh enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regµLation of CDKN1B. StimµLates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regµLation of insµLin receptor signaling throµgh PTPN6. Inactivates SSTR3 receptor function following heterodimerization. Immunogen:somatostatin receptor 2 Synonyms:Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Observed MW:41 kDa Uniprot ID:P30874 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, WB Recommended dilution:WB: 1:500-1:1000; IHC: 1:50-1:100 Gene ID:6752 Research Area:Signal Transduction, Metabolism