ELISA SPOP anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Component of a cµLlin-RING-based BCR(BTB-CµL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CµL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CµL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insµLin, by promoting PDX1/IPF1 degradation. The cµLlin-RING-based BCR(BTB-CµL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Immunogen:speckle-type POZ protein Synonyms:HIB homolog 1, Roadkill homolog 1, speckle type POZ protein, SPOP, TEF2 Observed MW:42 kDa Uniprot ID:O43791 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IP Recommended dilution:WB: 1:500-1:2000; IHC: 1:50-1:500; IP : 1:500-1:1000 Gene ID:8405 Research Area:Metabolism