ELISA SP100 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Together with PmL, this tumor suppressor is a major constituent of the PmL bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Throµgh the regµLation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Throµgh interaction with the MRN complex it may be involved in the regµLation of telomeres lengthening. May also regµLate TP53-mediated transcription and throµgh CASP8AP2, regµLate FAS-mediated apoptosis. Also plays a role in infection by viruses, including cytomegalovirus and Epstein-Barr virus, throµgh mechanisms that may involve chromatin and/or transcriptional regµLation. Immunogen:SP100 nuclear antigen Synonyms: Observed MW:100 kDa Uniprot ID:P23497 Reactivity: Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:6672 Research Area:Metabolism