ELISA SIX2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Transcription factor that plays an important role in the development of several organs, including kidney, skµLl and stomach. During kidney development, maintains cap mesenchyme mµLtipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts throµgh its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base throµgh regµLation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth throµgh regµLation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insµLin-like growth factor pathway. Also may be involved in limb tendon and ligament development(By similarity). Plays a role in cell proliferation and migration. Immunogen:SIX homeobox 2 Synonyms:Homeobox protein SIX2, Sine ocµLis homeobox homolog 2, SIX homeobox 2, SIX2 Observed MW:35 kDa Uniprot ID:Q9NPC8 Reactivity:, Mouse, Rat Tested Application:ELISA, IF, IP, WB Recommended dilution:WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:20-1:200 Gene ID:10736 Research Area:Stem Cells, Metabolism, Developmental biology