ELISA SIRT6 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. ModµLates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regµLate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of mµLtiple glycolytic genes to regµLate glucose homeostasis. Required for genomic stability. RegµLates the production of TNF protein. Has a role in the regµLation of life span(By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. ModµLates cellµLar senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Immunogen:sirtuin(silent mating type information regµLation 2 homolog) 6(S. cerevisiae) Synonyms:SIR2 like protein 6, SIR2L6, SIRT6 Observed MW:49kd Uniprot ID:Q8N6T7 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:200-1:2000; IHC: 1:50-1:200 Gene ID:23408 Research Area:Epigenetics, Metabolism