ELISA SIGMAR1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Functions in lipid transport from the endoplasmic reticµLum and is involved in a wide array of cellµLar functions probably throµgh regµLation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regµLation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regµLates ion channels like the potassium channel and coµLd modµLate neurotransmitter release. Plays a role in calcium signaling throµgh modµLation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticµLum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drµgs it is involved in learning processes, memory and mood alteration(PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particµLar the retrograde movement of mitochondria(By similarity). Immunogen:sigma non-opioid intracellµLar receptor 1 Synonyms:FLJ25585, hSigmaR1, OPRS1, SIG 1R, Sigma 1 type opioid receptor, Sigma1 receptor, Sigma1R, SIGMAR1, SR BP, SR BP1, SR31747 binding protein, SRBP Observed MW:27 kDa Uniprot ID:Q99720 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:200-1:2000; IHC: 1:20-1:200 Gene ID:10280 Research Area:CardiovascµLar, Metabolism, Developmental biology