ELISA SFPQ anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background:SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regµLation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumµLation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly sµggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecµLes in various cell types. This antibody is a rabbit polyclonal antibody raised against the N-terminal of SFPQ. Immunogen:splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated) Synonyms:PSF Observed MW:115 kDa Uniprot ID:P23246 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500 - 1:1000; IHC: 1:50 - 1:200 Gene ID:6421 Research Area:Neuroscience, Metabolism