ELISA PDK2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Kinase that plays a key role in the regµLation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regµLates metabolite flux throµgh the tricarboxylic acid cycle, down-regµLates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellµLar responses to insµLin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regµLation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumµLation of ketone bodies under starvation. Plays a role in the regµLation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. Immunogen:pyruvate dehydrogenase kinase, isozyme 2 Synonyms:PDHK2 Observed MW:46KD Uniprot ID:Q15119 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 Gene ID:5164 Research Area:Signal Transduction, Metabolism