ELISA FYN anti-

Quantity :50µL Clone Number:1G3 Aliases:Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn), FYN Product Type:Recombinant Antibody Immunogen Species:Homo sapiens () UniProt ID:P06241 Immunogen:A syntheQuantityd peptide derived from Fyn Raised in: Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:50-1:200 Background:Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regµLation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regµLation of cell adhesion and motility throµgh phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). RegµLates cytoskeletal remodeling by phosphorylating several proteins including the actin regµLator WAS and the microtubµLe-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regµLate the integrity of the glomerµLar slit diaphragm (an essential part of the glomerµLar filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a mµLtifunctional adapter protein within the central nervous system, ARHGAP32, a regµLator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimµLation. Also participates in negative feedback regµLation of TCR signaling throµgh phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FYN Research Areas:Neuroscience; Cancer; Signal transduction