ELISA SIRT5 anti-

Quantity :50µL Clone Number:9H12 Aliases:NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (RegµLatory protein SIR2 homolog 5) (SIR2-like protein 5), SIRT5, SIR2L5 Product Type:Recombinant Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NXA8 Immunogen:A syntheQuantityd peptide derived from SIRT5 Raised in: Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:50-1:200 Background:NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regµLation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). ModµLates ketogenesis throµgh the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SIRT5 Research Areas:Epigenetics and Nuclear Signaling; Cancer; CardiovascµLar; Metabolism