ELISA MAP2K6 anti-

Quantity :100µL Clone Number: Aliases:Dual specificity mitogen activated protein kinase kinase 6 antibody; Dual specificity mitogen-activated protein kinase kinase 6 antibody; MAP kinase kinase 6 antibody; MAP2K6 antibody; MAPK/ERK kinase 6 antibody; MAPKK 6 antibody; MAPKK6 antibody; MEK 6 antibody; MEK6 antibody; Mitogen Activated Protein Kinase Kinase 6 antibody; MKK 6 antibody; MKK6 antibody; MP2K6_ antibody; PRKMK6 antibody; protein kinase antibody; Protein kinase mitogen activated kinase 6 antibody; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6) antibody; SAPK kinase 3 antibody; SAPKK-3 antibody; SAPKK3 antibody; SKK3 antibody; Stress-activated protein kinase kinase 3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P52564 Immunogen:SyntheQuantityd peptide derived from N-terminal of MAP2K6. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regµLation of cellµLar responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 throµgh MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regµLated gene expression in response to IL-12 stimµLation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regµLation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation throµgh NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regµLator for melanocytes dendricity, throµgh the modµLation of Rho family GTPases. Raingeaud J., Mol. Cell. Biol. 16:1247-1255(1996). Stein B., J. Biol. Chem. 271:11427-11433(1996). Han J., J. Biol. Chem. 271:2886-2891(1996). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:MAP2K6 Research Areas:Cell biology;Immunology;Signal transduction