ELISA TXNIP anti-

Quantity :50µL Clone Number: Aliases:thioredoxin interacting protein Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9H3M7 Immunogen:Synthetic peptide of TXNIP Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; ELISA:1:2000-1:10000, IHC:1:30-1:150 Background:May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecµLe between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TXNIP Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Metabolism;Signal transduction