ELISA STAT2 (Ab-690) anti-

Quantity :100µL Clone Number: Aliases:Homo sapiens interferon alpha induced transcriptional activator antibody; interferon alpha induced transcriptional activator antibody; ISGF 3 antibody; ISGF3 antibody; MGC59816 antibody; P113 antibody; signal transducer and activator of transcription 2 113kD antibody; Signal transducer and activator of transcription 2 antibody; STAT113 antibody; Stat2 antibody; STAT2_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P52630 Immunogen:Peptide sequence around aa.688~692 (R-K-Y-L-K) derived from STAT2. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200 Background:STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regµLatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thoµght to be involved in the process of blocking IFN-a response by adenovirus. Fu, X. et al. (1992) Biochemistry 89, 7840-7843. Park, C. et al. (2000) Immunity 13, 795-804. Horvath, C. et al. (1996) MolecµLar and CellµLar Biology 16, 6957-6964. Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:STAT2 Research Areas:Epigenetics and Nuclear Signaling;Signal transduction