ELISA SIRPA anti-

Quantity :100µL Clone Number: Aliases:Signal regµLatory protein alpha type 1 antibody; Bit antibody; Brain Ig like molecµLe with tyrosine based activation motifs antibody; Brain Ig-like molecµLe with tyrosine-based activation motifs antibody; Brain immunoglobµLin like molecµLe with tyrosine based activation motifs antibody; CD172 antigen like family member A antibody; CD172 antigen-like family member A antibody; CD172a antibody; CD172a antigen antibody; Inhibitory receptor SHPS-1 antibody; Macrophage fusion receptor antibody; MFR antibody; MYD 1 antibody; Myd 1 antigen antibody; MyD-1 antigen antibody; p84 antibody; Protein tyrosine phosphatase non receptor type substrate 1 antibody; PTPNS1 antibody; SHP substrate 1 antibody; SHPS-1 antibody; SHPS1 antibody; SHPS1_ antibody; Signal regµLatory protein alpha 2 antibody; Signal regµLatory protein alpha 3 antibody; Signal regµLatory protein alpha antibody; Signal regµLatory protein alpha type 2 antibody; Signal-regµLatory protein alpha-1 antibody; Signal-regµLatory protein alpha-2 antibody; Signal-regµLatory protein alpha-3 antibody; SIRP antibody; Sirp-alpha-1 antibody; Sirp-alpha-2 antibody; Sirp-alpha-3 antibody; SIRPA antibody; SIRPalpha antibody; SIRPalpha1 antibody; SIRPalpha2 antibody; SIRPalpha3 antibody; Tyrosine phosphatase SHP substrate 1 antibody; Tyrosine protein phosphatase non receptor type substrate 1 antibody; Tyrosine-protein phosphatase non-receptor type substrate 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P78324 Immunogen:SyntheQuantityd peptide derived from SIRP-alpha1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:ImmunoglobµLin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellµLar signaling during synaptogenesis and in synaptic function By similarity. Involved in the negative regµLation of receptor tyrosine kinase-coupled cellµLar responses induced by cell adhesion, growth factors or insµLin. Mediates negative regµLation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Kentaro Ide, PNAS, Mar 2007; 104: 5062 - 5066. Thomas T. Chen, Cancer Res., Jan 2004; 64: 117 - 127. Shu Q. Liu, J. Biol. Chem., Nov 2005; 280: 39294 - 39301. Gurpreet S. Kapoor, Cancer Res., Sep 2004; 64: 6444 - 6452. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SIRPA Research Areas:Neuroscience;CardiovascµLar;Signal transduction