ELISA SYNCRIP anti-

Quantity :100µL Clone Number: Aliases:cytoplasmic RNA-interacting protein antibody; dJ3J17.2 antibody; Glycine and tyrosine rich RNA binding protein antibody; Glycine- and tyrosine-rich RNA-binding protein antibody; GRY RBP antibody; GRY-RBP antibody; GRYRBP antibody; Heterogeneous nuclear ribonucleoprotein Q antibody; hnRNP Q antibody; HNRPQ antibody; HNRPQ_ antibody; HNRPQ1 antibody; NS1 associated protein 1 antibody; NS1-associated protein 1 antibody; NSAP1 antibody; pp68 antibody; RP1 3J17.2 antibody; Synaptotagmin binding cytoplasmic RNA interacting protein antibody; Synaptotagmin-binding antibody; Syncrip antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O60506 Immunogen:SyntheQuantityd peptide derived from Internal of hnRNP Q. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500 Background:Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modµLate the postranscriptional C to U RNA-editing of the APOB mRNA throµgh either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport throµgh interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. Harris C.E., J. Virol. 73:72-80(1999). Du G., Chin. Sci. BµLl. 45:343-349(2000). Mourelatos Z., EMBO J. 20:5443-5452(2001). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SYNCRIP Research Areas:Epigenetics and Nuclear Signaling;Microbiology