ELISA DUT anti-

Quantity :50µL Clone Number: Aliases:Deoxyuridine 5' triphosphate nucleotidohydrolase; nuclear isoform antibody; Deoxyuridine 5'-triphosphate nucleotidohydrolase; mitochondrial antibody; Deoxyuridine triphosphatase antibody; dut antibody; DUT_ antibody; dUTP nucleotidohydrolase antibody; dUTP pyrophosphatase antibody; dUTPase antibody; FLJ20622 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P33316 Immunogen:Synthetic peptide of DUT Raised in:Rabbit Reactivity:, Rat Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50 Background:This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellµLar purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellµLar pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resµLting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DUT Research Areas:Epigenetics and Nuclear Signaling