ELISA TERT anti-

Quantity :50µL Clone Number: Aliases:CMM9 antibody; DKCA2 antibody; DKCB4 antibody; EST2 antibody; HEST2 antibody; htert antibody; hTRT antibody; PFBMFT1 antibody; TCS1 antibody; Telomerase associated protein 2 antibody; Telomerase catalytic subunit antibody; Telomerase reverse transcriptase antibody; Telomerase-associated protein 2 antibody; Telomere Reverse Transcriptase antibody; TERT antibody; TERT_ antibody; TP2 antibody; TRT antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14746 Immunogen:Synthetic peptide of TERT Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 Background:Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellµLar senescence, as it is normally repressed in postnatal somatic cells resµLting in progressive shortening of telomeres. DeregµLation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse sµggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the fµLl-length sequence of some variants has not been determined. Alternative splicing at this locus is thoµght to be one mechanism of regµLation of telomerase activity. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TERT Research Areas:Epigenetics and Nuclear Signaling;Cancer;Developmental biology;Stem cells