ELISA TYK2 (Ab-1054) anti-

Quantity :100µL Clone Number: Aliases:JTK 1 antibody; JTK1 antibody; Non receptor tyrosine protein kinase 2 antibody; Non receptor tyrosine protein kinase TYK2 antibody; Non-receptor tyrosine-protein kinase TYK2 antibody; OTTHUMP00000232745 antibody; OTTHUMP00000232746 antibody; OTTHUMP00000232748 antibody; Protein Tyrosine Kinase 2 antibody; TYK 2 antibody; Tyk2 antibody; TYK2_ antibody; Tyrosine kinase 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P29597 Immunogen:Peptide sequence around aa.1052~1056 (H-E-Y-Y-R) derived from TYK2. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; IHC:1:50-1:100 Background: TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promµLgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobµLin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobµLin E. Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730. Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TYK2 Research Areas:Signal transduction