ELISA SMUG1 anti-

Quantity :100µL Clone Number: Aliases:FDG antibody; HMUDG antibody; MGC104370 antibody; Single strand selective monofunctional uracil DNA glycosylase 1 antibody; Single strand selective monofunctional uracil DNA glycosylase antibody; Single-strand selective monofunctional uracil DNA glycosylase antibody; SMµg 1 antibody; Smµg1 antibody; SMµg1 protein antibody; SMµg1_ antibody; UNG 3 antibody; UNG3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q53HV7 Immunogen:SyntheQuantityd peptide derived from internal of SMµg1. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. Ide H., Biochemistry 42:5003-5012(2003). Sµgano S., Nat. Genet. 36:40-45(2004). Venter J.C., Submitted (JµL-2005). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMµg1 Research Areas:Epigenetics and Nuclear Signaling