ELISA SPIN1 anti-

Quantity :50µL Clone Number: Aliases:OCR antibody; Ovarian cancer-related protein antibody; SPIN antibody; Spin1 antibody; SPIN1_ antibody; Spindlin-1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y657 Immunogen:Recombinant Spindlin-1 protein (1-262AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at \\\'Lys-4\\\' and asymmetrically dimethylated at \\\'Arg-8\\\' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regµLation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovµLation to resume meiosis of oocytes blocked in prophase I: may act by regµLating maternal transcripts to control meiotic resumption. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SPIN1 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Developmental biology