ELISA UBQLN1 anti-

Quantity :50µg Clone Number: Aliases:DA41 antibody; DSK2 antibody; FLJ90054 antibody; hPLIC-1 antibody; hPLIC1 antibody; PLIC-1 antibody; PLIC1 antibody; Protein linking IAP with cytoskeleton 1 antibody; Ubiquilin-1 antibody; Ubiquilin1 antibody; UBQL1_ antibody; UBQLN1 antibody; UBQN antibody; XDRP1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UMX0 Immunogen:Recombinant Ubiquilin-1 protein (1-300AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Plays an important role in the regµLation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticµLum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumµLated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regµLation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regµLates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regµLation of the levels of PSEN1 by targeting its accumµLation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregµLating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimµLating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBQLN1 Research Areas:Cell biology