ELISA TIMELESS Antibody, HRP

Quantity :50µg Clone Number: Aliases:FLJ12640 antibody; FLJ20714 antibody; hTIM antibody; Protein timeless homolog antibody; TIM antibody; TIM_ antibody; TIM1 antibody; Timeless antibody; timeless circadian clock 1 antibody; timeless circadian clock antibody; timeless homolog antibody; TIMELESS1 antibody; Tof1 homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UNS1 Immunogen:Recombinant Protein timeless homolog protein (1004-1131AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throµghout normal DNA replication and in the regµLation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regµLates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regµLates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or µLtraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubµLes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TIMELESS Research Areas:Epigenetics and Nuclear Signaling