ELISA TPX2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:C20ORF1 antibody; C20orf2 antibody; Chromosome 20 Open Reading Frame 1 antibody; Differentially expressed in cancerous and non-cancerous lung cells 2 antibody; Differentially expressed in cancerous and noncancerous lung cells 2 antibody; Differentially expressed in lung cells 2 antibody; Differentially expressed in lung cells antibody; DIL 2 antibody; DIL-2 antibody; DIL2 antibody; FLS353 antibody; GD:C20orf1 antibody; HCA 519 antibody; HCA519 antibody; HCTP 4 antibody; HCTP4 antibody; HepatocellµLar carcinoma associated antigen 519 antibody; HepatocellµLar carcinoma-associated antigen 519 antibody; p100 antibody; Preferentially expressed in colorectal cancer antibody; Protein fls353 antibody; REPP 86 antibody; repp86 antibody; Restricted expression proliferation associated protein 100 antibody; Restricted expression proliferation-associated protein 100 antibody; Targeting protein for Xklp2 antibody; TPX 2 antibody; TPX2 antibody; TPX2 microtubµLe associated homolog antibody; TPX2 microtubµLe associated protein homolog antibody; TPX2 microtubµLe nucleation factor antibody; TPX2_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9µLW0 Immunogen:Recombinant Targeting protein for Xklp2 protein (160-320AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubµLes during apoptosis. Required for chromatin and/or kinetochore dependent microtubµLe nucleation. Mediates AURKA localization to spindle microtubµLes (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at \'Thr-288\' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimµLates local microtubµLe nucleation (PubMed:26165940). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TPX2 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology