ELISA SUFU anti-

Quantity :50µL Clone Number: Aliases:OTTHUMP00000020374 antibody; OTTHUMP00000020377 antibody; OTTHUMP00000020379 antibody; PRO1280 antibody; SU FU antibody; SU(F)U antibody; Su(fu) antibody; SUFU antibody; SUFU negative regµLator of hedgehog signaling antibody; SUFU_ antibody; SUFUH antibody; SUFUXL antibody; Suppressor of Fused antibody; Suppressor of fused homolog (Drosophila) antibody; Suppressor of fused homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UMX1 Immunogen:Recombinant Suppressor of fused homolog protein (325-484AA) Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 Background:Negative regµLator in the hedgehog signaling pathway. Down-regµLates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regµLator of beta-catenin signaling. RegµLates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the fµLl length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SUFU Research Areas:Epigenetics and Nuclear Signaling; Cancer