ELISA NDFIP1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:0610010M22Rik antibody; Breast cancer associated protein SGA 1M antibody; Breast cancer-associated protein SGA-1M antibody; MGC10924 antibody; N4WBP5 antibody; Ndfip1 antibody; Nedd4 family interacting protein 1 antibody; NEDD4 family-interacting protein 1 antibody; NEDD4 WW domain binding protein 5 antibody; NEDD4 WW domain-binding protein 5 antibody; NFIP1_ antibody; Putative MAPK activating protein PM13 antibody; Putative MAPK-activating protein PM13 antibody; Putative NF kappa B activating protein 164 antibody; Putative NF-kappa-B-activating protein 164 antibody; Putative NFKB and MAPK activating protein antibody; Putative NFKB and MAPK-activating protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BT67 Immunogen:Recombinant NEDD4 family-interacting protein 1 protein (2-116AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modµLates the stability of their targets. As a resµLt, controls many cellµLar processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regµLation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity (PubMed:19706893). ModµLates EGFR signaling throµgh mµLtiple pathways. In particµLar, may regµLate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably throµgh PTEN destabilization and on MAPK8 throµgh ITCH-dependent MAP2K4 inactivation. As a resµLt, may control cell growth rate (PubMed:20534535). Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases: NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NDFIP1 Research Areas:Epigenetics and Nuclear Signaling; Cell biology