ELISA POLR3B anti-

Quantity :50µg Clone Number: Aliases:C128 antibody; DNA directed RNA polymerase III 127.6 kDa polypeptide antibody; DNA directed RNA polymerase III subunit B antibody; DNA-directed RNA polymerase III 127.6 kDa polypeptide antibody; DNA-directed RNA polymerase III subunit B antibody; DNA-directed RNA polymerase III subunit RPC2 antibody; FLJ10388 antibody; polr3b antibody; Polymerase (RNA) III (DNA directed) polypeptide B antibody; RNA polymerase III subunit C2 antibody; RNA polymerase III subunit RPC2 antibody; RPC2 antibody; RPC2_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NW08 Immunogen:Recombinant DNA-directed RNA polymerase III subunit RPC2 protein (831-939AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:200-1:500 Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which syntheQuantitys small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellµLar bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B throµgh the RIG-I pathway. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:POLR3B Research Areas:Epigenetics and Nuclear Signaling