ELISA RASSF1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:123F2 antibody; Cardiac specific ras association domain family 1 protein antibody; cardiac-specific ras association domain family 1 protein; 123F2 antibody; NORE2A antibody; OTTHUMP00000195503 antibody; OTTHUMP00000195504 antibody; OTTHUMP00000195505 antibody; OTTHUMP00000195507 antibody; Pancreas specific ras association domain family 1 protein antibody; Ras association (RalGDS/AF 6) domain family member 1 antibody; Ras association domain-containing protein 1 antibody; RASF1_ antibody; Rassf1 antibody; RASSF1A antibody; RDA32 antibody; REH3P21 antibody; Tumor suppressor protein RDA32 antibody; WµgSC:H_LUCA12.5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NS23 Immunogen:Recombinant Ras association domain-containing protein 1 protein (23-145AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimµLation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resµLting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regµLating cell cycle progression at the level of G1/S-phase transition by regµLating accumµLation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RASSF1 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction