ELISA TBCD anti-

Quantity :50µg Clone Number: Aliases:Beta tubµLin cofactor D antibody; Beta-tubµLin cofactor D antibody; KIAA0988 antibody; SSD 1 antibody; SSD-1 antibody; SSD1 antibody; tbcd antibody; TBCD_ antibody; tfcD antibody; TubµLin folding cofactor D antibody; TubµLin specific chaperone D antibody; TubµLin-folding cofactor D antibody; TubµLin-specific chaperone D antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BTW9 Immunogen:Recombinant TubµLin-specific chaperone D protein (2-96AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 Background:TubµLin-folding protein implicated in the first step of the tubµLin folding pathway and required for tubµLin complex assembly. Involved in the regµLation of microtubµLe polymerization or depolymerization, it modµLates microtubµLe dynamics by capturing GTP-bound beta-tubµLin (TUBB). Its ability to interact with beta tubµLin is regµLated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubµLe disruption in absence of ARL2. Increases degradation of beta tubµLin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TBCD Research Areas:Cancer; Cell biology; Tags & Cell Markers; Signal transduction