ELISA UVRAG Antibody, HRP

Quantity :50µg Clone Number: Aliases:Beclin 1 binding protein antibody; DHTX antibody; Disrupted in heterotaxy antibody; p63 antibody; UV radiation resistance associated antibody; UV radiation resistance associated gene antibody; UV radiation resistance associated gene protein antibody; UV radiation resistance-associated gene protein antibody; UVRAG antibody; UVRAG_ antibody; VPS38 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9P2Y5 Immunogen:Recombinant UV radiation resistance-associated gene protein (375-425AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Versatile protein that is involved in regµLation of differenent cellµLar pathways implicated in membrane trafficking. Involved in regµLation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticµLum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303). During autophagy acts as regµLatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regµLation of degradative endocytic trafficking and cytokinesis, and in regµLation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UVRAG Research Areas:Epigenetics and Nuclear Signaling; Cancer; CardiovascµLar