ELISA ULBP2 anti-

Quantity :50µL Clone Number: Aliases:ALCAN alpha antibody; ALCAN-alpha antibody; N2DL 2 antibody; N2DL-2 antibody; N2DL2 antibody; N2DL2_ antibody; NKG2D ligand 2 antibody; NKG2D ligand 2 precursor antibody; NKG2DL2 antibody; RAET1H antibody; Retinoic acid early transcript 1 H antibody; Retinoic acid early transcript 1H antibody; µL16 binding protein 2 antibody; µL16-binding protein 2 antibody; µLBP2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BZM5 Immunogen:Recombinant NKG2D ligand 2 protein (26-216AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Ligand for the KLRK1/NKG2D receptor, together with at least µLBP1 and µLBP3. µLBPs activate mµLtiple signaling pathways in primary NK cells, resµLting in the production of cytokines and chemokines. Binding of µLBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein µL16. The interaction with µL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. µL16 also causes µLBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:µLBP2 Research Areas:Immunology