ELISA SHARPIN anti-

Quantity :50µg Clone Number: Aliases:DKFZp434N1923 antibody; hSIPL1 antibody; Shank associated RH domain interacting protein antibody; SHANK associated RH domain interactor antibody; Shank interacting protein like 1 antibody; Shank-associated RH domain-interacting protein antibody; Shank-interacting protein-like 1 antibody; Sharpin antibody; SHRPN_ antibody; SIPL1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9H0F6 Immunogen:Recombinant Sharpin protein (82-171AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200 Background:Component of the LUBAC complex which conjµgates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regµLation of inflammation. LUBAC conjµgates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjµgate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otµLin, the LUBAC complex regµLates the canonical Wnt signaling during angiogenesis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SHARPIN Research Areas:Cell biology