ELISA TREX1 anti-

Quantity :50µL Clone Number: Aliases:TREX1 antibody; Three-prime repair exonuclease 1 antibody; EC 3.1.11.2 antibody; 3'-5' exonuclease TREX1 antibody; Deoxyribonuclease III antibody; DNase III antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NSU2 Immunogen:Recombinant Three-prime repair exonuclease 1 protein (1-270AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC, IP; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 Background:Major cellµLar 3\\\'-to-5\\\' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3\\\' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumµLate in the cytosol and activate the IFN-stimµLatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3\\\' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TREX1 Research Areas:Epigenetics and Nuclear Signaling; Immunology