ELISA SNF8 Antibody, Biotin

Quantity :50µL Clone Number: Aliases:Dot3 antibody; ELL associated protein of 30 kDa antibody; ELL-associated protein of 30 kDa antibody; ESCRT-II complex subunit VPS22 antibody; hVps22 antibody; snf8 antibody; SNF8 ESCRTII complex subunit homolog (S cerevisiae) antibody; SNF8_ antibody; Vacuolar sorting protein SNF8 antibody; Vacuolar-sorting protein SNF8 antibody; VPS22 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96H20 Immunogen:Recombinant Vacuolar-sorting protein SNF8 protein (1-258AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for mµLtivesicµLar body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regµLation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SNF8 Research Areas:Epigenetics and Nuclear Signaling