ELISA RB1CC1 anti-

Quantity :50µg Clone Number: Aliases:FAK family kinase-interacting protein of 200 kDa antibody; FIP200 antibody; RB1-inducible coiled-coil protein 1 antibody; RB1CC1 antibody; RBCC1_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TDY2 Immunogen:Recombinant RB1-inducible coiled-coil protein 1 protein (1544-1594AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200 Background:Plays a role as a modµLator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. RegµLates early events but also late events of autophagosome formation throµgh direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regµLates repair of DNA damage induced by ionizing radiation and negatively regµLates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regµLation of neuronal homeostasis (By similarity). Implicated in the regµLation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regµLator of the RB1 pathway and a mediator that plays a crucial role in muscµLar differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RB1CC1 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Metabolism; Signal transduction